Antioxidant activity, Antinociceptive and anti-inflammatory effects of Pot marigold hydroalcoholic extract on experimental animals

This study was conducted to evaluate the analgesic and anti-inflammatory effects of hydroalcoholic extract of Pot marigold aerial part as an indigenous medicinal Iranian plant. Pot marigold (family Asteraceae) is an important plant of genus Calendula (marigolds), having several medicinal applications all over the world. In order to evaluate its analgesic activities hot water tail immersion and acetic acid writhing tests were used. The inflammation inhibitory effect was measured by carrageenan induced paw edema. Adult albino mice (2030g) and Wistar rats (200-220g) of both sexes were used for the experiment. The results of this study showed that aqueous extract of Pot marigold demonstrated significant differences comparing control and standard groups in all tests. Extracts showed a dose dependent effect on pain or inflammation inhibition. The present study could prove that Pot marigold is effective against pain and inflammation in a dose dependent manner.